A developmental lineage-based gene co-expression network for mouse pancreatic beta-cells

Mouse Pancreas Developmental Network - Osipovich et al

Results from iterative refined WGCNA network analysis. The file includes 2 tables in separate tabs. 1) Gene Membership: full listing of the 15,949 expressed genes in the dataset and their module/meta-module membership. This table provides gene names, select gene functional classification annotation (T2D associated expression change, transcription factor, signaling molecule or lincRNA), gene population specific expression, gene meta-module and module assignment in the network, eigengene connectivity (kMe), gene expression profile, and gene expression values in each sample (normalized counts). 2) Modules: details on the 91 module detected by our analysis, including module size, module-density, and module eigengenes.

  Enrichment Module Assignment Endoderm Pancreatic Endoderm Pancreatic MPCs Endocrine Beta cells
Gene T2D expression Signal TF lincRNA Population Specific Expression Meta-module Module kMe Profile Sox17 E8.0 Sox17 E8.5 Sox17 Epcam E9.5 Pdx1 E9.5 Ptf1a E10.5 Neurog3 E15.5 KO Neurog3 E15.5 Insm1 E15.5 KO Insm1 E15.5 Ins E16.5 Ins P60
Gene T2D expression Signal TF lincRNA Population Specific Expression Meta-module Module kMe Profile Sox17 E8.0 Sox17 E8.5 Sox17 Epcam E9.5 Pdx1 E9.5 Ptf1a E10.5 Neurog3 E15.5 KO Neurog3 E15.5 Insm1 E15.5 KO Insm1 E15.5 Ins E16.5 Ins P60

Legend
  • The data columns are averaged from the original raw count data (N=3 per sample). No normalization was performed.
  • Enrichment (T2D Expression, Signal, TF, lincRNA): Enrichment is indicated as "Enriched"
  • Module: UNCLASSIFIED is indicated as "-"
  • Meta-Module: UNCLASSIFIED is indicated as "-"